Updated: 10/10/2019

Acute Myelogenous Leukemia (AML)

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Snapshot
  • A 60-year-old man presents with fever, long-standing fatigue, and shortness of breath on exertion. He also complains of easy bruising and occasional bleeding from his gums. On physical exam, he has cervical lymphadenopathy and marked hepatosplenomegaly. Peripheral blood smear shows large blasts.
Introduction

  • Acute leukemia with pancytopenia
  • Epidemiology
    • median onset 65 years of age
  • Subtypes
    • M3 aka acute promyelocytic leukemia (APML) 
      • t(15;17) 
        • disruption of retinoic acid receptor (RAR) required for myeloblast maturation 
      • associated with DIC
      • presence of Auer rods
        • peroxidase positive eosinophilic cytoplasmic inclusions
    • acute megakaryoblastic leukemia 
      • associated with Down syndrome
      • < 5 years of age (recall leukemia in Down syndrome occurring in > 5 years of age = ALL)
    • acute monocytic leukemia
      • infiltration of gums
  • Risk factors
    • alkylating chemotherapy
    • radiation
    • myeloproliferative disorders
    • Down syndrome
Presentation
  • Symptoms of pancytopenia (high WBC count but WBCs are dysfunctional)
    • fatigue
    • dyspnea
    • infection due to dysfunctional blasts
    • bleeding
  • Physical exam
    • lymphadenopathy
    • fever
    • hepatosplenomegaly
Evaluation
  • Peripheral blood smear
    • > 20% blasts in blood smear
  • Most accurate test = flow cytometry
  • Bone marrow biopsy with cytogenetics     
    • myeloblasts with Auer rods in APL
    • myeloperoxidase (MPO) positive
  • CBC
    • anemia
    • thrombocytopenia
    • ↓ mature WBCs
Differential Diagnosis
  • ALL
  • Myelodysplastic syndrome
  • CML blast crisis
  • Leukemoid reaction
Treatment
  • Initial treatment with chemotherapy
    • to induce remission
    • cytarabine
  • Bone marrow transplant after remission
    • especially for cytogenetics revealing high chance of relapse
  • All-trans-retinoic acid (ATRA) to those with M3 (APL)
Prognosis, Prevention, and Complications
  • Prognosis
    • prognostic indicator is cytogenetics
    • 90% complete response rate from initial chemotherapy in those with good cytogenetics
    • relapse rate > 50% with median survival 3-12 months
  • Complications
    • febrile neutropenia
    • DIC
    • gout
    • tumor lysis syndrome
 

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(M1.ON.15.72) A 35-year-old male presents to his physician with the complaint of fatigue and weakness for six months. His physician orders a CBC which demonstrates anemia and thrombocytopenia. During the subsequent work up, a bone marrow biopsy is performed which ultimately leads to the diagnosis of acute promyelocytic leukemia. Which of the following translocations and fusion genes would be present in this patient? Tested Concept

QID: 106506
1

t(8;14) - BCR/Abl1

6%

(8/136)

2

t(9;22) - BCR/Abl1

7%

(9/136)

3

t(15;17) - PML/RARalpha

74%

(101/136)

4

t(14;18) - PML/RARalpha

5%

(7/136)

5

t(9;22) - PML/RARalpha

4%

(6/136)

M 1 D

Select Answer to see Preferred Response

(M1.ON.14.0) A 55-year-old male with fever, fatigue, generalized weakness, and bleeding gums for the past 3 weeks presents to his family physician. On exam, he has bilateral submandibular lymphadenopathy and hepatosplenomegaly. CBC demonstrates decreased RBCs and mature WBCs. The patient is referred to an oncologist, and a bone marrow aspiration is performed, demonstrating >20% myeloblasts with Auer rods that are myeloperoxidase positive. What is the most likely chromosomal translocation that is responsible for this patient's clinical presentation and lab results? Tested Concept

QID: 106974
1

15;17

67%

(91/135)

2

9;22

17%

(23/135)

3

14;18

5%

(7/135)

4

11;14

3%

(4/135)

5

8;14

7%

(9/135)

M 1 E

Select Answer to see Preferred Response

(M1.ON.13.49) A 62-year-old female presents to your office with a sore throat, low-grade fever, and bleeding gums. Peripheral blood smear for this patient is shown in Figure A. Which of the following is most likely to be abnormally elevated in this patient? Tested Concept

QID: 101359
FIGURES:
1

Plasma cells

4%

(1/26)

2

Myeloblasts

62%

(16/26)

3

Lymphoblasts

19%

(5/26)

4

Metamyeloctes

12%

(3/26)

5

Platelets

4%

(1/26)

M 2 E

Select Answer to see Preferred Response

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