Snapshot A 59-year-old woman presents to her primary care physician with overwhelming fatigue, headaches, and some blurry vision. She is worried that old age is finally catching up. While she is happy about losing 10 lbs over the past month, she is also confused since she has not changed her diet or exercise routine. On further questioning, she reveals that she is extremely itchy after a hot bath or shower. She is otherwise healthy. A blood smear shows RBC precursors. Introduction Myeloproliferative neoplasm characterized by increased production of RBCs login to view 1 more bullet Epidemiology login to view 1 more bullet Pathogenesis login to view 6 more bullets Associated conditions login to view 3 more bullets Prognosis login to view 1 more bullet Presentation Symptoms login to view 13 more bullets Physical exam login to view 7 more bullets Evaluation Labs login to view 9 more bullets Bone marrow biopsy login to view 4 more bullets Differential Diagnosis Secondary polycythemia login to view 2 more bullets Tumor-driven polycythemia Other myeloproliferative neoplasm Treatment Reduce risk of thrombosis login to view 3 more bullets Myelosuppression login to view 1 more bullet Gout prophylaxis login to view 1 more bullet Complications Thrombosis login to view 1 more bullet Peptic ulcers login to view 1 more bullet Gout login to view 1 more bullet Progression to login to view 3 more bullets