Introduction Neoplasia of mature myeloid cells (mostly megakaryocytes) login to view 1 more bullet Caused by a JAK2 kinase mutation Seen mainly in older adults (5th-6th decade) Presentation Symptoms login to view 1 more bullet Prognosis, Prevention, and Complications May progress to acute leukemia or myelofibrosis High risk of venous thrombosis login to view 1 more bullet