Updated: 12/30/2019

Essential Thrombocytosis

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Introduction
  • Neoplasia of mature myeloid cells (mostly megakaryocytes)
    • typically high levels of erythrocytes, granulocytes are also seen
  • Caused by a JAK2 kinase mutation 
  • Seen mainly in older adults (5th-6th decade)
Presentation
  • Symptoms
    • bleeding
Prognosis, Prevention, and Complications
  • May progress to acute leukemia or myelofibrosis
  • High risk of venous thrombosis
    • also increased risk of bleeding due to dysfunction of neoplastic platelets
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