Essential Thrombocytosis

Introduction

Neoplasia of mature myeloid cells (mostly megakaryocytes) typically high levels of erythrocytes, granulocytes are also seen Caused by a JAK2 kinase mutation  Seen mainly in older adults (5th-6th decade)

Presentation

Symptoms bleeding

Prognosis, Prevention, and Complications

May progress to acute leukemia or myelofibrosis High risk of venous thrombosis also increased risk of bleeding due to dysfunction of neoplastic platelets