Introduction May have carcinoma in situ (CIS) or squamous cell carcinoma (SCC) carcinoma in situ Bowen's disease leukoplakia on the shaft of the penis or scrotum peak incidence > 50 years associated with HPV 16 minority of cases progresses to SCC Erythroplasia of Queyrat erythroplakia on the glans/prepuce only the location distinguishes Bowen's from Queyrat's Bowenoid papulosis multiple papular lesions affects at a younger age than Bowden/Queyrat associated with HPV 16 does not progress to SCC Squamous cell carcinoma (SCC) more common in Asia, Africa, and South America most common sites are prepuce/glans commonly associated with HPV 16 and 18 smoking lack of circumcision increases risk only if man is not hygienic Prognosis, Prevention, and Complications Metastasis SCC may seed to inguinal and iliac nodes