Snapshot A 68-year-old man presents to his primary care physician for an annual examination. He reports new-onset lower back pain. He also endorses unintentional weight loss and night sweats. Family history is remarkable for prostate cancer in his father. He has tenderness upon palpation in his lumbar spine. Digital rectal examination is notable for an asymmetric and nodular prostate. Prostate-specific antigen level is elevated at 35 ng/mL. Radiography of his lumbar spine demonstrates lytic bone lesions. Introduction Overview login to view 3 more bullets Epidemiology login to view 7 more bullets Presentation Symptoms login to view 5 more bullets Physical exam login to view 2 more bullets Studies Serum labs login to view 4 more bullets Invasive studies login to view 4 more bullets Differential Benign prostate hyperplasia login to view 2 more bullets Treatment Treatment dependent on pathological features, metastasis, and the patient's life expectancy login to view 2 more bullets Complications Obstructive uropathy