Please confirm topic selection

Are you sure you want to trigger topic in your Anconeus AI algorithm?

Please confirm action

You are done for today with this topic.

Would you like to start learning session with this topic items scheduled for future?

Updated: Aug 26 2019

Vaginal Carcinoma

  • Snapshot
    • A 62-year-old woman reports having abnormal vaginal bleeding that occurs intermittently between her predictable menstrual cycles. Pelvic examination is notable for a vaginal mass. She underwent a vaginal biopsy that was remarkable for squamous cell carcinoma.
  • Introduction
    • Overview
      • malignancy affecting the vagina
        • most common histologic type is squamous cell carcinoma
          • most commonly secondary to squamous cell carcinoma of the cervix
    • Epidemiology
      • incidence
        • comprises ~3% of all malignancies involving the female genital tract
        • mean age of diagnosis is ~60 years
      • risk factors
        • human papillomavirus (HPV) infection
        • extension from malignant cervical disease
        • diethylstilbestrol (DES)
          • associated with adenocarcinoma of the vagina
  • Presentation
    • Symptoms
      • vaginal bleeding (most common)
        • may be postcoital, intermenstrual, or postmenopausal
    • Physical exam
      • vaginal mass may be noted
  • Studies
    • Lab studies
      • vaginal cytology
    • Invasive studies
      • vaginal colposcopy
        • indication
          • performed if cytology is abnormal
      • vaginal biopsy
        • indication
          • confirms the diagnosis
    • Histology
      • squamous cell carcinoma
        • most common histological type
      • clear cell adenocarcinoma
        • secondary to DES exposure in utero
        • typically presents in women < 20 years of age
      • sarcoma botryoides ("botrys" is Greek for "grapes")
        • affecting girls < 4 years of age
        • appears as a polypoid (or grape-like) mass that emerges from the vagina
        • contains spindle-shaped cells that are positive for desmin
  • Differential
    • Cervical cancer
      • differentiating factors
        • evidence of dysplastic or malignat cells in the cervix only
  • Treatment
    • Treatment planning should be individualized depending upon the location, size, and clinical stage of the tumor
  • Complications
    • Teatment-related complications
      • rectal and vaginal strictures
      • urethral, bladder, and/or rectal injury
1 of 0
1 of 2
Private Note

Attach Treatment Poll
Treatment poll is required to gain more useful feedback from members.
Please enter Question Text
Please enter at least 2 unique options
Please enter at least 2 unique options
Please enter at least 2 unique options