Updated: 4/5/2022

Soft Tissue Tumors

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  • Lipoma
    • Introduction
      • most common benign soft tissue tumor in adults
      • soft, well-encapsulated fat tumor
    • Differential diagnosis
      • ganglion cysts
        • synovial herniation over underlying tendon sheath or joint
        • dorsal wrist commonly affected, but volar wrist can also be affected
        • asymptomatic, painless
        • transilluminates with light
          • distinguishes ganglion cysts from solid masses such as lipomas
    • Treatment
      • simple excision typically curative
  • Liposarcoma
    • Introduction
      • most common malignant soft tissue tumor in adults
      • malignant fat tumor that can be large
    • Evaluation
      • lipoblast is the characteristic cell
    • Treatment
      • will recur without full excision
  • Rhabdomyoma
    • Introduction
      • benign tumor derived from striated muscle (skeletal or cardiac)
        • most common cardiac tumor in children
      • associated conditions
        • tuberous sclerosis
          • specifically rhabdomyoma of the heart
  • Rhabdomyosarcoma
    • Introduction
      • most common malignant soft tissue tumor of childhood
      • arises from skeletal muscle
      • typically involves head/neck, vagina
    • Evaluation
      • rhabdomyoblast is characteristic cell
        • desmin positive stains

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