Updated: 12/11/2016

Platinum Analogs

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Topic
Cisplatin and Carboplatin
  • Mechanism
    • crosslinks DNA
      • platinum atom binds to DNA bases
  • Clinical use
    • testicular cancer
    • bladder cancer
    • ovarian cancer
    • lung cancer
  • Toxicity
    • nephrotoxicity
      • prevent with
        • amifostine
          • free radical scavenger
        • hydration
    • deafness 
      • acoustic nerve damage

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Questions (2)
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(M1.ON.17.4697) A 65-year-old male presents to the physician after noticing gross blood with urination. He reports that this is not associated with pain. The patient smokes 1.5 packs per day for 45 years. Dipstick analysis is positive for blood, with 5 RBC per high-power field (HPF) on urinalysis. A cystoscopy is performed, which is significant for a lesion suspicious for malignancy. A biopsy was obtained, which is suggestive of muscle-invasive transitional cell carcinoma. Before radical cystectomy is performed, the patient is started on cisplatin-based chemotherapy. Which of the following is most likely associated with this chemotherapeutic drug? Tested Concept

QID: 108157
1

Gentamicin enhances toxicity risk

46%

(45/97)

2

Cardiotoxicity

9%

(9/97)

3

Hemorrhagic cystitis

24%

(23/97)

4

Myelosuppression

14%

(14/97)

5

Addition of mesna decreases drug toxicity

4%

(4/97)

M 3 C

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