Cisplatin and Carboplatin Mechanism crosslinks DNA platinum atom binds to DNA bases Clinical use testicular cancer bladder cancer ovarian cancer lung cancer Toxicity nephrotoxicity prevent with amifostine free radical scavenger hydration deafness acoustic nerve damage
QUESTIONS 1 of 2 1 2 Previous Next Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (M1.ON.17.4697) A 65-year-old male presents to the physician after noticing gross blood with urination. He reports that this is not associated with pain. The patient smokes 1.5 packs per day for 45 years. Dipstick analysis is positive for blood, with 5 RBC per high-power field (HPF) on urinalysis. A cystoscopy is performed, which is significant for a lesion suspicious for malignancy. A biopsy was obtained, which is suggestive of muscle-invasive transitional cell carcinoma. Before radical cystectomy is performed, the patient is started on cisplatin-based chemotherapy. Which of the following is most likely associated with this chemotherapeutic drug? Tested Concept QID: 108157 Type & Select Correct Answer 1 Gentamicin enhances toxicity risk 46% (45/97) 2 Cardiotoxicity 9% (9/97) 3 Hemorrhagic cystitis 24% (23/97) 4 Myelosuppression 14% (14/97) 5 Addition of mesna decreases drug toxicity 4% (4/97) M 3 Question Complexity C Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 1 Review tested concept