Vinca Alkaloids (Vincristine and Vinblastine) Mechanism block microtubule formation bind to tubulin in M phase prevent polymerization of microtubules prevent formation of mitotic spindle Clinical use Hodgkin's lymphoma part of the MOPP regimen M = mustargen O = oncovin = vincristine brand name Procarbazine Prednisone Wilms' tumor choriocarcinoma ALL testicular cancer Kaposi's sarcoma Toxicity vincristine neurotoxicity areflexia peripheral neuritis paralytic ileus vinblastine myelosuppression Taxols (Paclitaxel) Mechanism block microtubule breakdown hyperstabilize microtubules in M phase mitotic spindle cannot break down anaphase cannot occur Clinical use ovarian cancer breast cancer Toxicity peripheral neuropathy myelosuppression hypersensitivity