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Updated: Aug 22 2019

Microtubule Inhibitors

  • Vinca Alkaloids (Vincristine and Vinblastine)
    • Mechanism
      • block microtubule formation
        • bind to tubulin in M phase
        • prevent polymerization of microtubules
        • prevent formation of mitotic spindle
    • Clinical use
      • Hodgkin's lymphoma
        • part of the MOPP regimen
          • M = mustargen
          • O = oncovin = vincristine brand name
          • Procarbazine
          • Prednisone
      • Wilms' tumor
      • choriocarcinoma
      • ALL
      • testicular cancer
      • Kaposi's sarcoma
    • Toxicity
      • vincristine
        • neurotoxicity
          • areflexia
          • peripheral neuritis
          • paralytic ileus
      • vinblastine
        • myelosuppression
  • Taxols (Paclitaxel)
    • Mechanism
      • block microtubule breakdown
        • hyperstabilize microtubules in M phase
        • mitotic spindle cannot break down
        • anaphase cannot occur
    • Clinical use
      • ovarian cancer
      • breast cancer
    • Toxicity
      • peripheral neuropathy
      • myelosuppression
      • hypersensitivity
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