Definitions and Concepts Growth fraction login to view 8 more bullets Cell-cycle specificity login to view 5 more bullets Log-kill hypothesis login to view 2 more bullets Cell Cycle S phase login to view 9 more bullets M phase login to view 3 more bullets Sites of Action Sites of Action Mechanism of Action Drugs Mechanism Nucleotide synthesis Methotrexate 5-FU ↓ thymidine synthesis 6-MP ↓ purine synthesis DNA Alkylating agentsCisplatin Cross-link DNA Dactinomycin Doxorubicin Intercalate DNA Etoposide Inhibit topoisomerase II Cellular division Vinca alkaloids Inhibit MT formation Paclitaxel Inhibit MT disassembly Important Toxicities Important Toxicities Drugs Toxicities Bleomycin Pulmonary fibrosis Cisplatin and Carboplatin Acoustic nerve damage and nephrotoxicity Cyclophosphamide Hemorrhagic cystitis Doxorubicin Cardiotoxicity Methotrexate, 5-FU, and 6-MP Myelosuppression Vincristine Peripheral neuropathy Development of resistance Tumors can develop resistance to anticancer drugs through a variety of mechanisms login to view 20 more bullets Combination drug regimens prevent the development of resistance