Snapshot mycosis fungoides A 55-year-old man complains of a rash he has had for many months. It occasionally itches. While he has tried some topical over-the-counter steroids, he has not seen his dermatologist yet since the symptoms were mild. On physical exam, his legs are covered with multiple well-demarcated red papules and plaques with some telangiectasias. A skin biopsy is obtained. A week later, the biopsy comes back with Pautrier microabsecesses, lymphocytic infiltrate, and cells with cerebriform nuclei. Introduction Both are variants of cutaneous T-cell lymphoma (CTCL) login to view 1 more bullet Mycosis fungoides (50-70% of CTCLs) login to view 1 more bullet Sézary syndrome (1-3% of CTCLs) login to view 2 more bullets Epidemiology login to view 3 more bullets Presentation Symptoms login to view 1 more bullet Physical exam login to view 11 more bullets Evaluation Physical exam to assess for lymphadenopathy and organomegaly Diagnosis usually made by clinical exam and history Diagnosis confirmed with skin biopsy login to view 2 more bullets Labs login to view 1 more bullet Differential Diagnosis Adult T-cell leukemia-lymphoma (ATLL) Atopic dermatitis Psoriasis Drug eruption (SJS) Treatment Pharmacologic options login to view 4 more bullets Prognosis, Prevention, and Complications Prognosis login to view 5 more bullets Complications login to view 2 more bullets