Updated: 2/13/2018

Oncogenes

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Overview
  • Mechanism
    • gain of function mutation in a proto-oncogene
    • due to novel protein function only one allele change needed for neoplasia
  • Categories of proto-oncogenes
    • growth factor overproduction
    • growth factor receptor upregulation
      • e.g., HER2/neu
    • signal transducer
      • e.g., ras
    • cell cycle regulators
  • Examples
Gene
Associated Tumor
Mechanism
BCR:ABL CML 9;22 translocation 
BCL-2 Follicular and undifferentiated lymphomas
14;18 translocation
CCND1 Mantle cell lymphomas 11;14 translocation
C-Myc Burkitt's lymphoma 8;14 translocation
L-Myc Lung tumor amplification
N-MYC Neuroblastoma amplification
ERB-B2 Breast, ovarian, and gastric carcinomas amplification
CDK4 Melanoma amplification
RET Multiple endocrine neoplasia IIA and B  point mutation
C-KIT Gastrointestinal stromal tumor (GIST) point mutation
RAS Colon carcinoma point mutation
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