Genetic Diseases ConditionNeoplasmDown syndromeALL (presents > 5 years old) and AML- megakaryoblastic (< 5 years old)Xeroderma pigmentosumMelanoma, basal cell carcinoma, and squamous cell carcinomas of skinAlbinismMelanoma, basal cell carcinoma, and squamous cell carcinomas of skinTuberous sclerosisAstrocytoma, angiomyolipoma, and cardiac rhabdomyoma Disease Resulting From Environmental Exposure ConditionNeoplasmActinic keratosisSquamous cell carcinoma of skinBarrett's esophagusEsophageal adenocarcinomaDysplastic nevusMalignant melanomaRadiation exposureAML, CML, and papillary thyroid cancer Diseases Associated with the Immune System ConditionNeoplasmUlcerative colitisColonic adenocarcinomaImmunodeficiencyMalignant lymphomasAIDSMalignant lymphomas and Kaposi's sarcomaHPV High risk types (16,18,31,33)Squamous cell carcinomaAutoimmune diseases (e.g. Hashimoto's thyroiditis and myasthenia gravis)Lymphoma (marginal cell type) Miscellaneous Diseases ConditionNeoplasmPlummer-Vinson syndromeSquamous cell carcinoma of esophagusCirrhosis (alcoholic, hepatitis B or C)Hepatocellular carcinomaPaget's disease of boneSecondary osteosarcoma and fibrosarcomaAcanthosis nigricansVisceral malignancy (stomach, lung, breast, and uterus)