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Updated: Oct 28 2019


  • Snapshot
    • A 45-year-old woman with lung adenocarcinoma presents to the infusion center for her chemotherapy treatment. She had previously tolerated her treatment, but this infusion includes a newer chemotherapy agent. Fifteen minutes into her infusion, she feels very nauseous. The physician supervising prescribes her an anti-emetic medicine commonly used in the setting of chemotherapy.
  • Introduction
    • Drugs
      • ondansetron
    • Mechanism of action
      • serotonin (5-HT3) receptor antagonist, which decreases vagal stimulation
    • Clinical use
      • anti-emesis
        • particularly in the setting of chemotherapy or procedure
    • Adverse effects
      • QT prolongation
      • serotonin syndrome
      • headache
      • constipation
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