Sucralfate Mechanism provides physical protection to ulcer base requires low pH to activate into a paste consistency that adheres to the mucosal wall action may be inhibited by antacids Clinical use ↑ ulcer healing ↓ ulcer recurrence Bismuth subsalicylate Mechanism similar to sucralfate Clinical use ↑ ulcer healing traveler's diarrhea quadruple therapy of H. pylori ulcers (BMT regimen) Bismuth Metronidazole Tetracycline (amoxicillin) PPI Toxicity harmless black coloring of stool