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Updated: Sep 7 2017

Bile Secretion

  • Overview
    • Bile
      • necessary for digestion and absorption of lipids in gastrointestinal system
      • synthesized and secreted by liver, stored in gallbladder
    • Bile composition
      • bile salts
        • synthesis
          • cholesterol → primary bile acids → secondary bile acids → bile salts
        • conjugation
          • liver conjugates bile acids with amino acids (glycine, taurine) to form bile salts
          • conjugation changes pKs of bile acids, increasing water solubility
        • function
          • emulsification of dietary lipids
          • formation of micelles with products of lipid digestion
      • bile pigments
        • e.g., bilirubin
      • cholesterol
      • phospholipids
      • electrolytes (aka ions)
      • water
  • Bile Secretion
    • Secretory pathway
      • cholecystokinin (CCK)
        • stimulates (1) contraction of gallbladder and (2) relaxation of sphincter of Oddi
          • bile flows gallbladder → duodenum
            • bile emulsifies and solubilizes dietary lipids in small intestine
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