Snapshot A 17-year-old boy is seen after his annual colonoscopy. His mother and his older brother both died of colorectal cancer. Since 12 years old, he has been screened annually for colorectal cancer. This year, several hundred polyps are seen in his colon. Based on his own readings and his physician’s recommendation, he decides to undergo prophylactic colectomy. Introduction Thousands of polyps in the intestinal tract from genetic mutation Genetics login to view 5 more bullets Associated conditions login to view 10 more bullets Presentation Symptoms login to view 4 more bullets Physical exam login to view 4 more bullets Evaluation Based on endoscopy, family history, and genetic testing Complete blood count with iron deficiency anemia Endoscopy with biopsy login to view 1 more bullet Genetic testing login to view 1 more bullet Differential Peutz-Jegher syndrome Lynch syndrome Treatment Prophylactic surgical colectomy Routine screening with colonoscopy and endoscopy Prognosis, Prevention, and Complications Prognosis login to view 1 more bullet Complications login to view 6 more bullets