Review Question - QID 210422

A 71-year-old man presents to his oncologist with nausea. He recently underwent chemotherapy for pancreatic cancer and has developed severe intractable nausea over the past week. He vomits several times a day. His past medical history is notable for gout, osteoarthritis, and major depressive disorder. He takes allopurinol and sertraline. He has a 15-pack-year smoking history and drinks 1 glass of wine per day. His temperature is 98.6°F (37°C), blood pressure is 148/88 mmHg, pulse is 106/min, and respirations are 22/min. On exam, he is lethargic but able to answer questions appropriately. He has decreased skin turgor and dry mucous membranes. He is started on a medication to treat nausea. However, 3 days later he presents to the emergency room with fever, agitation, hypertonia, and clonus. What is the most likely mechanism of action of the drug this patient was prescribed?