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Snapshot
  • A 45-year-old woman with lung adenocarcinoma presents to the infusion center for her chemotherapy treatment. She had previously tolerated her treatment, but this infusion includes a newer chemotherapy agent. Fifteen minutes into her infusion, she feels very nauseous. The physician supervising prescribes her an anti-emetic medicine commonly used in the setting of chemotherapy.
Introduction
  • Drugs
    • ondansetron
  • Mechanism of action
    • serotonin (5-HT3) receptor antagonist, which decreases vagal stimulation
  • Clinical use 
    • anti-emesis
      • particularly in the setting of chemotherapy or procedure
  • Adverse effects
    • QT prolongation
    • serotonin syndrome
    • headache
    • constipation  

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