0%
Topic
Review Topic
0
0
N/A
N/A
Questions
1
0
0
Topic
Snapshot
  • A 25-year-old man with a history of ulcerative colitis presents to his gastroenterologist. His ulcerative colitis had been calm but recently he developed rectal bleeding and increasingly frequent stools. A colonoscopy shows diffuse inflammatory changes localized to the rectum. He is started on topical mesalazine as well as oral sulfasalazine, which contains both an anti-inflammatory and anti-bacterial component.
Introduction
  • Drugs
    • sulfasalazine
  • Mechanism of action
    • activated by gut bacteria and metabolized into sulfapyridine and 5-aminosalicylic acid (5-ASA)
    • 5-ASA
      • anti-inflammatory (COX inhibitor)
      • inhibits leukotriene synthesis and lipoxygenase
    • sulfapyridine
      • anti-bacterial
  • Clinical use
    • inflammatory bowel disease
      • ulcerative colitis
      • Crohn disease
    • juvenile rheumatoid arthritis
  • Adverse effects
    • gastrointestinal upset
    • drug rash
    • hemolytic anemia in those with G6PD deficiency
    • malaise
    • reversible oligospermia
    • contraindications
      • allergy to sulfa medicines
      • porphyria

References

Please rate topic.

Average 5.0 of 2 Ratings

Questions (1)
Question locked
Sorry, this question is for
PEAK Premium Subscribers only
Upgrade to PEAK
EXPERT COMMENTS (0)
Private Note