Topic
Review Topic
0
0
Snapshot
  • A 55-year-old man with a history of chronic NSAID use and recent hospitalization for a soft tissue infection presents to his primary care physician for diarrhea. His long-term medication list also includes ibuprofen, metoprolol, and most recently misoprostol given his long-term NSAID use. His physician is worried about C. difficile diarrhea, but the patient reports that this diarrhea started soon after starting misoprostol, which pre-dated his recent hospitalization and antibiotic use.
Introduction
  • Drugs
    • misoprostol
  • Mechanism of action
    • misoprostol is a prostaglandin E1 (PGE1) analog, which strengthens the gastric mucous barrier and ↓ acid production
    • it also ↓ degree of fat malabsorption
  • Clinical use
    • non-steroidal anti-inflammatory drug (NSAIDs) -induced peptic ulcer prophylaxis
      • NSAIDs block PGE1 production
    • induction of labor
      • PGE1 ripens the cervix
  • Adverse effects
    • diarrhea
    • abdominal pain
    • abortive
      • contraindicated in women of childbearing age
 

Please rate topic.

Average 5.0 of 1 Ratings

Thank you for rating! Please vote below and help us build the most advanced adaptive learning platform in medicine

The complexity of this topic is appropriate for?
How important is this topic for board examinations?
How important is this topic for clinical practice?
Topic COMMENTS (2)
Private Note