Updated: 9/8/2021

Proton Pump Inhibitors

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Questions
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Evidence
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Topic
Omeprazole
  • Other agents: lansoprazole and pantoprazole
  • Mechanism
    • irreversibly inhibits H+/K+-ATPase in gastric parietal cells   
      • H+/K+-ATPase is a primary active transporter
  • Clinical use
    • peptic ulcer disease
      • well-documented in literature as most effective agent 
    • gastritis
    • GERD
    • Zollinger-Ellison syndrome
    • Eradication of H. pylori
  • Toxicity 
    • P-450 inhibitor

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Questions (4)
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(M1.GI.13.3) A 37-year-old woman presents to your office with heartburn. Following an extensive workup, you diagnose her with a duodenal ulcer secondary to H. pylori infection. You prescribe triple therapy of omeprazole, clarithromycin, and amoxicillin. Which of the following best describes the mechanism of action of omeprazole?

QID: 101060
1

SST2 receptor agonist

0%

(0/176)

2

Parasympathetic inhibition

2%

(4/176)

3

Reversible block of H2 receptors

23%

(40/176)

4

Inhibition of primary active transport

69%

(122/176)

5

Inhibition of 50S ribosomal subunit

3%

(5/176)

M 1 E

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Evidence (4)
EXPERT COMMENTS (3)
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