Omeprazole Other agents: lansoprazole and pantoprazole Mechanism irreversibly inhibits H+/K+-ATPase in gastric parietal cells H+/K+-ATPase is a primary active transporter Clinical use peptic ulcer disease well-documented in literature as most effective agent gastritis GERD Zollinger-Ellison syndrome Eradication of H. pylori Toxicity P-450 inhibitor