Snapshot A 24-year-old medical student is 2 weeks into her first surgery rotation when her senior resident tells her that her eyes look a little yellow. She experienced her first needle stick injury in the operating room just 1 week earlier and began to worry about hepatitis. Other than rarely having the time to eat at work, she has no other complaints or symptoms. Introduction Hereditary unconjugated hyperbilirubinemia due to login to view 4 more bullets Autosomal recessive inheritance login to view 1 more bullet Presentation Symptoms login to view 2 more bullets Studies Normal laboratory tests including hepatic function Isolated unconjugated hyperbilirubinemia login to view 1 more bullet Rifampin test can be used to diagnose Gilbert login to view 2 more bullets Treatment Benign condition No treatment required Complications Associated with increased risk of cholelithiasis Increased severity and duration of neonatal jaundice Drug-interaction and increased susceptibility to toxic effects with irinotecan