Snapshot A 17-year-old female presents to the emergency department with complaints of subjective fever and crampy abdominal pain for the past week. Today, she had an episode of bloody bowel movement, which has never happened before. A physical examination demonstrates mild conjunctival pallor but is otherwise unremarkable. ESR and CRP are elevated. Introduction Clinical definition login to view 4 more bullets Epidemiology login to view 7 more bullets Pathogenesis login to view 7 more bullets Associated conditions login to view 13 more bullets Presentation Symptoms login to view 7 more bullets Physical exam login to view 3 more bullets Imaging Abdominal radiograph login to view 2 more bullets Barium enema login to view 2 more bullets Computed tomography (CT) or magnetic resonance imaging (MRI) login to view 1 more bullet Colonoscopy with biopsy login to view 8 more bullets Studies Stool studies login to view 1 more bullet Complete blood count, albumin, electrolytes, an markers of inflammation (e.g., ESR) login to view 1 more bullet Perinuclear antineutrophil cytoplasmic antibody (pANCA) Differential Crohn disease login to view 2 more bullets Infectious colitis login to view 2 more bullets Treatment Management of the disease is dependent on the disease severity and extent of involvement First-line login to view 7 more bullets Second-line login to view 2 more bullets Third-line login to view 3 more bullets Complications Anemia Bleeding/hemorrhage Perforation Toxic megacolon Colorectal cancer login to view 1 more bullet Osteoporosis Strictures