Snapshot A 50-year-old woman complains of increased regurgitation, especially when lying down. Her father had esophageal cancer at a young age, and she is worried about also having it. She is slightly overweight and has had GERD for the past 3 years. While her PCP makes a note in her file, she reassures the patient that she does meet the requirements for routine screening for esophageal cancer, but the physician will keep an eye out on her GERD. In the meantime, the physician prescribes a proton-pump inhibitor for daily use. Introduction Metaplastic transformation of esophageal lining login to view 3 more bullets Result of chronic gastroesophageal reflux disease (GERD) Pathogenesis login to view 2 more bullets Risk factors login to view 4 more bullets Associated conditions login to view 1 more bullet Presentation Symptoms login to view 2 more bullets Physical exam login to view 1 more bullet Evaluation Diagnosis with upper endoscopy with biopsy showing both login to view 3 more bullets Differential Diagnosis Erosive esophagitis Gastritis Treatment Lifestyle modifications login to view 2 more bullets Proton pump inhibitor for GERD Regular endoscopic surveillance to monitor risk of dysplasia and carcinoma Prognosis, Prevention, and Complications Prognosis login to view 5 more bullets Complications login to view 2 more bullets