Overview Pancreatic enzymes pancreas secretes enzymes required for digestion of carbohydrates, proteins, and lipids carbohydrates pancreas secretes α-amylase in active form digests 1,4-glycosidic bonds of carbohydrates (starch) lipids lipase-colipase pancreas secretes (active) lipase hydrolyzes triglycerides → 1 monoglyceride + 2 fatty acids lipase is inactivated by bile salts pancreas secretes (inactive) procolipase in intestinal lumen, trypsin activates procolipase procolipase (inactive) → colipase (active) colipase displaces inhibitory bile salts permits digestive functions of lipase phospholipase A2 pancreas secretes (inactive) phospholipase A2 in intestinal lumen, trypsin activates phospholipase A2 hydrolyzes phospholipids → lysolecithin + fatty acids proteins pancreas secretes proteases in inactive forms called proenzymes/zymogens trypsinogen chymotrypsinogen proelastase procarboxypeptidase A/B activation of pancreatic proteases brush-border enterokinase/enteropeptidase activates trypsinogen trypsinogen (inactive) → trypsin (active) trypsin catalyzes conversion of inactive precursors to active enzymes trypsinogen → trypsin (positive feedback loop) chymotrypsinogen → chymotrypsin proelastase → elastase procarboxypeptidase A/B →carboxypeptidase A/B pancreatic proteases hydrolyze dietary protein to absorbable molecules amino acids, dipeptides, tripeptides
QUESTIONS 1 of 3 1 2 3 Previous Next Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (M1.GI.14.31) A 55-year-old woman presents with acute onset abdominal pain radiating to her back, nausea, and vomiting. CT scan suggests a diagnosis of acute pancreatitis. The pathogenesis of acute pancreatitis relates to inappropriate activation of trypsinogen to trypsin. Which of the following activates trypsin in normal digestion? Tested Concept QID: 100096 Type & Select Correct Answer 1 Amylase 6% (10/155) 2 Lipase 10% (15/155) 3 Cholecystokinin 12% (19/155) 4 Enterokinase 66% (103/155) 5 Secretin 5% (7/155) M 1 Question Complexity E Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 4 Review tested concept
All Videos (1) Login to View Community Videos Login to View Community Videos Pancreatic Overview Keshav Mudgal Gastrointestinal - Pancreatic Enzymes D 2/19/2016 61 views 5.0 (1)