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Updated: Apr 21 2014

GI Secretory Products

  • Overview
      • Product
      • Source
      • Action
      • Regulation
      • Notes
      • Intrinsic Factor (IF)
      • parietal cells (stomach-body)
      • binds vitamin B12
      • mediate svitamin B12 absorption interminal ileum
      • -
      • autoimmune destruction of parietal cells causes (1) chronic gastritis and (2) pernicious anemia
      • gastrectomy results in loss of parietal cells and loss of IF; patient requires B12 injection to prevent pernicious anemia
      • Gastric Acid (HCl)
      • parietal cells (stomach-body)
      • ↓ stomach pH
      • ↑ by vagal stimulation (ACh), gastrin, histamine
      • ↓ by somatostatin, GIP, prostaglandin, secretin
      • gastrinoma is a gastrin-secreting tumor that causes (1) continuous high levels of HCl secretion and (2) gastric ulcers
      • Pepsin
      • chief cells (stomach-body)
      • protein digestion
      • ↑ by vagal stimulation (ACh)
      • chief cells secrete inactive pepsinogen, coverted to active pepsin at low pH
      • HCO3-
      • mucosal cells (stomach, duodenum, salivary glands, pancreas)
      • Brunner's glands (duodenum)
      • acid neutralization
      • ↑ pancreatic secretion by secretin
      • HCO3- is trapped in mucus that covers the gastric epithelium
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