Snapshot A 30-year-old man presents to the physician with his wife with concerns that they have been unable to get pregnant after trying for the past year. The patient's wife has undergone a female infertility workup with no positive results. On physical examination, the man has scant hair in the axilla and pubic areas, small and firm testes, and the finding seen in the image. Karyotype testing is performed and reveals the presence of an extra X chromosome. Overview Introduction Overview login to view 1 more bullet Epidemiology login to view 5 more bullets Pathophysiology login to view 6 more bullets Presentation Symptoms login to view 6 more bullets Physical exam login to view 5 more bullets Studies Karyotype login to view 2 more bullets Serum hormone levels login to view 4 more bullets Differential Double Y males (47,XYY) login to view 2 more bullets Fragile X syndrome login to view 2 more bullets Marfan syndrome login to view 2 more bullets Treatment Medical login to view 3 more bullets Lifestyle login to view 3 more bullets Complications ↑ risk of breast cancer login to view 2 more bullets