Finasteride Mechanism 5α-reductase inhibitor ↓ conversion of testosterone to dihydrotestosterone Indications BPH male-pattern baldness both hairloss and prostate hyperplasia are DHT driven processes Flutamide Mechanism testosterone receptor blocker Indications prostate carcinoma Ketoconazole Mechanism steroid synthesis inhibitor inhibits desmolase used at higher doses than as an anti-fungal Indications PCOS specifically the symptoms of hirsutism androgen receptor-positive prostate cancer Toxicity gynecomastia, amenorrhea Spironolactone Mechanism inhibits steroid binding Indications PCOS specifically the symptoms of hirsutism K-sparing diuretic Toxicity gynecomastia, amenorrhea