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Updated: Jan 6 2016

Cervical Pap Smear

  • Introduction
    • Screening test
      • can detect squamous dysplasia and cancer
      • can evaluate patient's sex hormones
        • superficial squamous cells
          • indicates full mucosal surface maturation and therefore the presence of estrogen
          • high estrogen without progesterone results in 100% superficial squamous cells
        • intermediate squamous cells
          • indicates presence of progesterone
          • high progesterone in pregnancy results in 100% intermediate cells
        • parabasal cells
          • indicates lack of estrogen and progesterone
          • seen in elderly women
    • Process
      • must sample transition zone between endo (columnar) and exo (squamous) cervix
      • smear must show presence of columnar cells to prove that transition zone was reached
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