Tamoxifen Mechanism estrogen antagonist in breast estrogen agonist in endometrium, bone Indications estrogen-receptor positive breast cancer Toxicity ↑ risk of DVTs ↑ risk of endometrial cancer secondary to agonist activity induces menopause hot flashes prevents osteoporosis secondary to agonist action in bone Raloxifene Mechanism estrogen antagonist in breast estrogen agonist in bone Indications osteoporosis in menopausal women Toxicity ↑ risk of DVTs induces menopause hot flashes NO ↑ risk of endometrial cancer secondary to antagonist activity in endometrium