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Updated: Oct 9 2022

Selective Estrogen Receptor Modulators (SERMs)

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  • Tamoxifen
    • Mechanism
      • estrogen antagonist in breast
      • estrogen agonist in endometrium, bone
    • Indications
      • estrogen-receptor positive breast cancer
    • Toxicity
      • ↑ risk of DVTs
      • ↑ risk of endometrial cancer
        • secondary to agonist activity
      • induces menopause
        • hot flashes
      • prevents osteoporosis
        • secondary to agonist action in bone
  • Raloxifene
    • Mechanism
      • estrogen antagonist in breast
      • estrogen agonist in bone
    • Indications
      • osteoporosis in menopausal women
    • Toxicity
      • ↑ risk of DVTs
      • induces menopause
        • hot flashes
      • NO ↑ risk of endometrial cancer
        • secondary to antagonist activity in endometrium
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