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Review Question - QID 210913

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QID 210913 (Type "210913" in App Search)
A 27-year-old man and his wife present to an infertility clinic for evaluation after they tried unsuccessfully to conceive for 2 years. He has no prior medical history and does not currently take any medications. On evaluation, he is found to have long extremities and gynecomastia. In addition, he has testicular atrophy and very little body hair, which is distributed primarily in the pubic region. Further analysis reveals azoospermia, and appropriate tests confirming the diagnosis are performed. The couple is told about the cause of their inability to conceive and given further options to pursue. Which of the following is associated with the pathophysiology underlying this patient's disorder?