Overview Overview hypothalamic-pituitary axis controls 2 functions of testes spermatogenesis synthesis and secretion of male sex steroid hormones login to view 1 more bullet Hypothalamic-pituitary axis hypothalamus GnRH login to view 5 more bullets pituitary LH login to view 8 more bullets FSH login to view 10 more bullets Negative feedback testosterone (via Leydig cells) testosterone acts on hypothalamus login to view 1 more bullet testosterone acts on anterior lobe of pituitary login to view 1 more bullet inhibin (via Sertoli cells) inhibin acts on anterior lobe of pituitary login to view 1 more bullet