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Updated: Sep 18 2018

Pseudohermaphroditism

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https://upload.medbullets.com/topic/116021/images/pseudo.jpg
  • Introduction
    • Mismatch in sex between the external genitalia and gonads (testes/ovaries)
      • named based on the genotype present
    • Female pseudohermaphrodite (XX)
      • due to excessive and inappropriate exposure to androgenic steroids during early gestation
      • most commonly seen in
        • congenital adrenal hyperplasia
        • exogenous administration of androgens during pregnancy
    • Male pseudohermaphrodite (XY)
      • due to decreased effective testosterone concentration
      • most commonly due to androgen insensitivity syndrome
        • aka testicular feminization
  • Presentation
    • Physical exam
      • female pseudohermaphrodite (XX)
        • ovaries present
        • external genitalia is virilized or ambiguous
      • male pseudohermaphrodite (XY)
        • testes present
        • external genitalia is female or ambiguous
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