Snapshot A 65-year-old man presents with worsening left-sided hearing loss and mild headache. He reported that his symptoms began a few months prior to presentation. He denies starting any new medications but has noticed he can no longer fit the hat he has owned for many years. Physical examination is unremarkable. Laboratory testing is notable for an elevated serum alkaline phosphatase. A radiograph of the skull is shown. Introduction Clinical definition a progressive metabolic bone disorder of abnormal bone remodeling there is excessive bone resorption and formation resulting in immature woven bone with collagen fibers arranged irregularly Background adult bone constantly undergoes bone remodeling and is accomplished by osteoclasts contains receptor activator for NF-κB (RANK) transmembrane receptors which responds to RANK ligand (RANKL) on osteoblasts and osteocytes to differentiate and activate in order to resorb bone osteocytes secrete growth factors to regulate bone formation bone formation is stimulated when mechanical forces are applied to bone contains RANKL osteoblasts contain RANKL and osteoprotegerin (OPG) OPG inhibits RANKL from binding to RANK on osteoclasts, thus inhibiting bone remodeling functions in bone formation bone matrix has two histological forms woven has less structural integrity seen in fetal development and fracture repair always considered abnormal in adults lamellar has more structural integrity Pathogenesis genetic and environmental factors may be involved increased multinucleated osteoclastic and osteoblastic activity leads to a high bone remodeling rate, leading to abnormal bone architecture phases lytic phase intense osteoclastic resorption mixed phase resorption and compensatory bone formation sclerotic phase osteoblastic bone formation predominates all three phases may co-exist in the same bone Associated findings neurologic nerve root compression hearing loss spinal stenosis orthopedic pathologic fractures secondary osteoarthritis oncologic osteosarcoma cardiovascular high-output heart failure labs normal serum phosphate, calcium, and parathyroid hormone elevated alkaline phosphatase histology mosaic pattern of lamellar bone with prominent cement lines Normal Biology and Anatomy adult bone constantly undergoes bone remodeling and is accomplished by osteoclasts contains receptor activator for NF-κB (RANK) transmembrane receptors which responds to RANK ligand (RANKL) on osteoblasts and osteocytes to differentiate and activate in order to resorb bone osteocytes secrete growth factors to regulate bone formation bone formation is stimulated when mechanical forces are applied to bone contains RANKL osteoblasts contain RANKL and osteoprotegerin (OPG) OPG inhibits RANKL from binding to RANK on osteoclasts, thus inhibiting bone remodeling functions in bone formation bone matrix has two histological forms woven has less structural integrity seen in fetal development and fracture repair always considered abnormal in adults lamellar has more structural integrity Laboratory Abnormalities in Select Bone DisordersEtiologySerum PhosphateSerum CalciumSerum Alkaline PhosphataseParathyroid HormoneOsteomalacia/ricketsDecreasedDecreasedIncreasedIncreasedOsteoporosisNormalNormalNormalNormalOsteopetrosisNormalNormal or decreasedNormalNormalPaget disease of boneNormalNormalElevatedNormalOsteitis fibrosa cysticaPrimaryhyperparathyroidismdecreasedSecondaryhyperparathyroidismincreasedPrimaryhyperparathyroidismincreasedSecondaryhyperparathyroidismdecreasedPrimary and secondary hyperparathyroidismincreasedPrimary and secondary hyperparathyroidismincreasedHypervitaminosis DIncreasedIncreasedNormalDecreased Presentation Symptoms usually asymptomatic bone and/or joint pain bone deformity bowing deformity hearing loss with skull involvement that lead to narrowing of the auditory foramen Physical exam typically unremarkable Treatment Medical bisphosphonates mechanism of action impregnates the bone that will be acted upon by osteoclasts when osteoclasts release the bisphosphonates during resorption, it impairs osteoclast activity
QUESTIONS 1 of 4 1 2 3 4 Previous Next Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (M1.MK.13.7) A 55-year-old male presents with left hip pain and stiffness. Radiographs are shown in Figures A and B. Serum alkaline phosphatase levels are elevated. A biopsy of the left femur is performed and shown in Figure C. Which of the following cells are initially responsible for this condition? QID: 101944 FIGURES: A B C Type & Select Correct Answer 1 Osteoblasts 25% (24/95) 2 Osteoclasts 71% (67/95) 3 Neutrophils 0% (0/95) 4 T-Cells 0% (0/95) 5 Fibroblasts 2% (2/95) M 2 Question Complexity E Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 2 Review Tested Concept Review Full Topic
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