Snapshot A 50-year-old man presents with a swollen ankle joint. He reports having had a warm, swollen, and non-painful right ankle for about a year. His past medical history includes long-standing alcoholism, diabetes, and diabetic neuropathy with foot ulcers. On physical exam, his right ankle is warm, erythematous, and non-tender. Radiography reveals joint effusion and resorption of bone. Inflammatory markers are not elevated on laboratory evaluation. Introduction Clinical definition login to view 1 more bullet Epidemiology login to view 15 more bullets Pathogenesis login to view 3 more bullets Associated conditions login to view 7 more bullets Presentation Symptoms login to view 1 more bullet Physical exam login to view 6 more bullets Imaging Radiography login to view 9 more bullets Magnetic resonance imaging (MRI) with gadolinium login to view 4 more bullets Bone scintigraphy (typically, technetium-99m-labeled methylene diphosphonate followed by indium-labeled leukocyte scintigraphy) login to view 5 more bullets Evaluation Labs login to view 1 more bullet Making the diagnosis login to view 1 more bullet Differential Cellulitis login to view 2 more bullets Osteomyelitis login to view 3 more bullets Treatment Conservative login to view 6 more bullets Operative login to view 4 more bullets Complications Spontaneous fractures Osteomyelitis