Snapshot A 7-year-old girl is brought to the pediatrician by her mother due to vaginal bleeding. The mother reports that her daughter appears happy, playful, and does exceptionally well in school. The mother says that she is in a healthy relationship with her husband, and the patient is an only child. The mother also states that the daughter reports pain "in her bones" and "stiffness." On physical exam, the patient is conversational and not shy. There is tenderness to palpation of the lower extremities and a hyperpigmented spot with ragged edges on the left leg. Breast development is noted, and there is mild blood in the vaginal introitus without trauma to the external and internal vagina. The patient is referred to a pediatric endocrinologist. Introduction Clinical definition login to view 6 more bullets Epidemiology login to view 4 more bullets Pathogenesis login to view 1 more bullet Genetics login to view 6 more bullets Presentation Symptoms login to view 5 more bullets Physical exam login to view 4 more bullets Imaging Radiographs login to view 6 more bullets Studies Labs login to view 1 more bullet Differential Neurofibromatosis type I login to view 1 more bullet Treatment There are no specific treatments for McCune-Albright syndrome login to view 1 more bullet Complications Increased risk for fracture