Select a Community
Are you sure you want to trigger topic in your Anconeus AI algorithm?
You are done for today with this topic.
Would you like to start learning session with this topic items scheduled for future?
Decreased mineralization of bone
0%
0/0
Decreased volume of bone
Excessive vitamin D consumption
Increased parathyroid hormone function
Increased remodeling of bone
Select Answer to see Preferred Response
This patient who presents with low back pain, progressive hearing loss, and an isolated increase in alkaline phosphatase most likely has Paget disease of bone. The pathophysiology underlying this disease is increased remodeling of bone. Paget disease of bone occurs when increased osteoclastic activity results in abnormally rapid turnover and remodeling of bone. This increased rate of activity results in the disorganization of bony architecture and is associated with sequelae such as pathologic fractures. In addition, the remodeled bone can impinge upon nerves in tight spaces and result in hearing loss, radiculopathy, and spinal stenosis. Patients will therefore often complain of bony pain as well as a neurologic deficit. Laboratory evaluation of Paget disease of bone reveals an elevated alkaline phosphatase level but normal calcium and potassium levels. Layfield presents the current state of knowledge about the mechanisms underlying the development of Paget disease of bone. He discusses how the increased rate of osteoclastic activity may be driven by abnormal RANK function. Incorrect Answers: Answer 1: Decreased mineralization of bone describes osteomalacia, which can also present with low back pain and compression fractures of the vertebrae; however, this disease would have decreased calcium and phosphate levels. Answer 2: Decreased volume of bone describes osteoporosis, which can also present with back pain due to low energy fractures; however, this disease would present with normal alkaline phosphatase levels. Answer 3: Excessive vitamin D consumption can result in hypervitaminosis D, which would present with anorexia, weakness, fatigue, and bone pain; however, this disease would present with increased calcium and phosphate levels. Answer 4: Increased parathyroid hormone function can also cause back pain because it results in bone remodeling and cyst formation; however, this disease would present with increased calcium levels. Bullet Summary: Paget disease of bone is caused by increased osteoclast activity resulting in increased remodeling of bone.
0.0
(0)
Please Login to add comment