Snapshot A 40-year-old woman with a past medical history of alcoholism presents to her physician's office for pain with swallowing. She had been experiencing heartburn for the past few weeks. She also reports pain with swallowing for the past few days. She reports having occasional abdominal pain and severe migraines for which she had been taking multiple doses of aspirin and ibuprofen daily. She reports variable intake during the day but consistent intake of ibuprofen at bedtime. This is often done without water. She is counseled on the side effects of nonsteroidal anti-inflammatory drugs and given alternative medication for her migraines. (Pill-induced esophagitis) Introduction Cyclooxygenase Inibitors Nonsteroidal anti-inflammatory drugs (NSAIDs) login to view 4 more bullets Mechanism login to view 2 more bullets Non-Selective NSAIDs Drugs login to view 1 more bullet Mechanism login to view 1 more bullet Clinical uses login to view 3 more bullets Toxicity login to view 8 more bullets Aspirin Drug login to view 1 more bullet Mechanism login to view 1 more bullet Clinical uses login to view 3 more bullets Toxicity login to view 18 more bullets Selective COX-2 Inhibitors Drug login to view 1 more bullet Mechanism login to view 5 more bullets Clinical use login to view 2 more bullets Toxicity login to view 2 more bullets