Snapshot A 50-year-old woman presents to her primary care physician's office for persistently dry eyes and mouth. She reports that this started several months ago and has not improved. She has been using artificial tears for the past few weeks without much relief. She also reports feeling very tired and anxious. She has a past medical history of systemic lupus erythematosus and a family history of rheumatoid arthritis. Physical exam reveals dry mucous membranes, swollen parotid glands, and conjunctivitis on exam. She is prescribed pilocarpine and sent for an autoimmune workup. Introduction Clinical definition login to view 1 more bullet Epidemiology login to view 9 more bullets Pathogenesis login to view 5 more bullets Associated conditions login to view 10 more bullets Prognosis login to view 1 more bullet Presentation Symptoms login to view 8 more bullets Physical exam login to view 9 more bullets Studies Labs login to view 4 more bullets Corneal staining to assess ocular damage Labial salivary gland biopsy login to view 4 more bullets Making the diagnosis login to view 1 more bullet Differential Diabetes Hepatitis C Anticholinergic drug use Mumps Treatment Medical login to view 10 more bullets Complications Dental caries Oral candidiasis Corneal abrasion or ulceration Mucosa-associated lymphoid tissue (MALT) lymphoma Parotid gland infection