Snapshot An 8-year-old boy is brought to his pediatrician for developing multiple bruises over the course of the school year. The patient's mother believes the child is being bullied at school. The patient is otherwise healthy. Family history is significant for his father expiring at 38 yearas of age due to a severe subarachnoid hemorrhage. On physical exam, there are ecchymoses and hematomas over the shins and knees. The skin also appears fragile and thin, which demonstrates a venous pattern in the extremities. The child undergoes genetic testing to confirm the diagnosis. Introduction Clinical definition login to view 5 more bullets Epidemiology login to view 3 more bullets Etiology login to view 12 more bullets Pathogenesis login to view 13 more bullets Presentation Symptoms/Physical exam login to view 4 more bullets Studies Making the diagnosis login to view 2 more bullets Differential Marfan syndrome Osteogenesis imperfecta Treatment Management approach login to view 2 more bullets Complications Vascular EDS login to view 6 more bullets Valvular involvement may require cardiac valve replacement