Updated: 2/12/2018

Sildenafil / Vardenafil

Average 5.0 of 4 Ratings

Topic

Review Topic

N/A

Questions

Evidence

Topic

Mechanism
- cGMP phosphodiesterase inhibitor
  - results in less cGMP degradation and ↑ cGMP
- Drives smooth muscle relaxation in the corpus cavernosum
  - ↑ blood flow to penis

Indications
- Erectile dysfunction
- Pulmonary hypertension

Toxicity
- Side effects
  - headache
  - flushing
  - dyspepsia
  - impaired blue-green color vision
- Do not co-administer with nitrates
  - risk of life-threatening hypotension

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Flashcards (0)

Cards

1 of 0

Action	Numeric Key	Letter Key	Function Key
Show Bullets		S	Enter (frontside only)
20%	1	N
40%	2	H
60%	3	F	Enter (backside only)
80%	4	E
100%	5	M
Toss	0	T

Questions (1)

(M1.RP.13.43) A 57-year-old male presents with a primary complaint of erectile dysfunction. After proper evaluation, the patient is started on daily administration of sildenafil. This medication directly causes accumulation of which of the following intracellular mediators?

QID: 101261

Type & Select Correct Answer

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Ca2+

(4/221)

cGMP

80%

(177/221)

AMP

(3/221)

16%

(35/221)