Updated: 2/12/2018

Sildenafil / Vardenafil

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Questions
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Evidence
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Topic
Mechanism
  • cGMP phosphodiesterase inhibitor
    • results in less cGMP degradation and ↑ cGMP 
  • Drives smooth muscle relaxation in the corpus cavernosum
    • ↑ blood flow to penis

Indications
  • Erectile dysfunction
  • Pulmonary hypertension
Toxicity
  • Side effects
    • headache
    • flushing
    • dyspepsia
    • impaired blue-green color vision
  • Do not co-administer with nitrates
    • risk of life-threatening hypotension

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Average 5.0 of 4 Ratings

Questions (1)

(M1.RP.13.43) A 57-year-old male presents with a primary complaint of erectile dysfunction. After proper evaluation, the patient is started on daily administration of sildenafil. This medication directly causes accumulation of which of the following intracellular mediators?

QID: 101261
1

Ca2+

2%

(3/164)

2

cGMP

76%

(124/164)

3

AMP

2%

(3/164)

4

NO

20%

(32/164)

5

ANP

1%

(1/164)

M 1 E

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Evidence (1)
EXPERT COMMENTS (2)
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