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Snapshot
  • A 24-year-old G1P0 patient presents to a local clinic at 10 weeks of pregnancy. She is interested in an elective abortion but does not want to undergo any surgical procedures or take any oral medications. She reports she heard of a gel suppository that is used to ripen the cervix for labor but also has abortifacient effects.
Introduction
  • Drugs
    • dinoprostone
      • vaginal suppository
  • Mechanism of action
    • prostaglandin E2 (PGE2)
      • causes increased uterine tone and relaxed cervical smooth muscle
  • Clinical use
    • cervical ripening
    • pregnancy termination
  • Adverse effects
    • abnormal uterine contractions
    • gastrointestinal upset
    • rarely, uterine rupture
 

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