Updated: 4/21/2017

Progestins

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Mechanism
  • Progesterone receptor agonist
    • ↓ endometrial proliferation 
      • proliferation is estrogen driven
    • ↑ maturity/vascularization of endometrium
Indications
  • Oral contraceptives
    • added to estrogen to prevent unopposed estrogen action on endometrium
  • Endometrial cancer
    • inhibits hyperplasia
  • Abnormal uterine bleeding
    • stabilizes endometrium

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