Updated: 12/24/2018

Selective Estrogen Receptor Modulators (SERMs)

0%
Topic
Review Topic
0
0
N/A
N/A
Questions
2
0
0
0%
0%
Evidence
2
0
0
Topic
Tamoxifen
  • Mechanism
    • estrogen antagonist in breast
    • estrogen agonist in endometrium, bone
  • Indications
    • estrogen-receptor positive breast cancer
  • Toxicity
    • ↑ risk of DVTs
    • ↑ risk of endometrial cancer
      • secondary to agonist activity
    • induces menopause
      • hot flashes
    • prevents osteoporosis
      • secondary to agonist action in bone
Raloxifene
  • Mechanism 
    • estrogen antagonist in breast
    • estrogen agonist in bone
  • Indications
    • osteoporosis in menopausal women
  • Toxicity
    • ↑ risk of DVTs
    • induces menopause
      • hot flashes
    • NO ↑ risk of endometrial cancer
      • secondary to antagonist activity in endometrium

Please rate topic.

Average 5.0 of 2 Ratings

Questions (2)
Evidence (2)
EXPERT COMMENTS (7)
Private Note