Updated: 4/5/2018

Clomiphene

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Mechanism
  • Partial estrogen receptor agonist
    • See Female Hypothalamic-Pituitary Axis topic
  • Acts specifically in hypothalamus which antagonizes normal negative feedback inhibition
  • Results in an ↑ release of LH and FSH from pituitary
    • stimulates ovulation
Indications
  • Infertility
  • PCOS 
Toxicity
  • Ovarian enlargement
  • Multiple birth pregnancy
  • Visual disturbances 
  • Hot flashes
 

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