Mechanism Estrogen receptor agonist Indications Hypogonadism/ovarian failure Menstrual abnormalities Hormone replacement therapy in postmenopausal women to treat menopausal symptoms login to view 1 more bullet osteoporosis login to view 1 more bullet Androgen-dependent prostate cancer Contraindications ER-positive breast cancer thrombophilic disorders Toxicity Postmenopausal bleeding Thrombophilia Breast tenderness Increased risk of endometrial cancer login to view 1 more bullet CVA clear cell adenocarcinoma of vagina login to view 2 more bullets breast cancer