Updated: 2/12/2018

Antiandrogens

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Questions
4
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Evidence
5
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Topic
Finasteride
  • Mechanism
    • 5α-reductase inhibitor
      • ↓ conversion of testosterone to dihydrotestosterone
  • Indications
    • BPH
    • male-pattern baldness
      • both hairloss and prostate hyperplasia are DHT driven processes
Flutamide
  • Mechanism
    • testosterone receptor blocker
  • Indications
    • prostate carcinoma
Ketoconazole
  • Mechanism
    • steroid synthesis inhibitor
      • inhibits desmolase 
    • used at higher doses than as an anti-fungal
  • Indications
    • PCOS
      • specifically the symptoms of hirsutism
    • androgen receptor-positive prostate cancer
  • Toxicity
    • gynecomastia, amenorrhea
Spironolactone
  • Mechanism
    • inhibits steroid binding
  • Indications
    • PCOS
      • specifically the symptoms of hirsutism
    • K-sparing diuretic
  • Toxicity
    • gynecomastia, amenorrhea

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Average 3.6 of 5 Ratings

Questions (4)
Evidence (5)
VIDEOS & PODCASTS (1)
EXPERT COMMENTS (10)
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