Finasteride Mechanism 5α-reductase inhibitor ↓ conversion of testosterone to dihydrotestosterone Indications BPH male-pattern baldness both hairloss and prostate hyperplasia are DHT driven processes Flutamide Mechanism testosterone receptor blocker Indications prostate carcinoma Ketoconazole Mechanism steroid synthesis inhibitor inhibits desmolase used at higher doses than as an anti-fungal Indications PCOS specifically the symptoms of hirsutism androgen receptor-positive prostate cancer Toxicity gynecomastia, amenorrhea Spironolactone Mechanism inhibits steroid binding Indications PCOS specifically the symptoms of hirsutism K-sparing diuretic Toxicity gynecomastia, amenorrhea
QUESTIONS 1 of 4 1 2 3 4 Previous Next Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (M1.RP.15.75) A 19-year-old South Asian male presents to the family physician concerned that he is beginning to go bald. He is especially troubled because his father and grandfather "went completely bald by the age of 25," and he is willing to try anything to prevent his hair loss. The family physician prescribes a medication that prevents the conversion of testosterone to dihydrotestosterone. Which of the following enzymes is inhibited by this medication? QID: 106838 Type & Select Correct Answer 1 Desmolase 2% (2/112) 2 Aromatase 8% (9/112) 3 5-alpha-reductase 88% (99/112) 4 cGMP phosophodiesterase 1% (1/112) 5 Cyclooxygenase 2 1% (1/112) M 1 Question Complexity D Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 3 Review Tested Concept Review Full Topic (M1.RP.13.14) A 75-year-old male is diagnosed with advanced metastatic prostate cancer. After further evaluation and staging, the patient is started on flutamide therapy. Addition of which of the following medications to this patient’s medication regimen would be of greatest benefit in the treatment of this patient’s condition? QID: 100315 Type & Select Correct Answer 1 Leuprolide 68% (143/211) 2 Anastrozole 13% (28/211) 3 Clomiphene 4% (9/211) 4 Tamoxifen 6% (13/211) 5 Cyproterone 6% (12/211) M 3 Question Complexity E Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 1 Review Tested Concept Review Full Topic (M1.RP.13.60) A 57-year-old presents to your clinic complaining of baldness. He is overweight, has been diagnosed with BPH, and is currently taking atorvastatin for hyperlipidemia. The patient has tried several over-the-counter products for hair-loss; however, none have been effective. After discussing several options, the patient is prescribed a medication to treat his baldness that has the additional benefit of treating symptoms of BPH as well. Synthesis of which of the following compounds would be expected to decrease in response to this therapy? QID: 100361 Type & Select Correct Answer 1 GnRH 6% (9/154) 2 DHT 75% (115/154) 3 LH 1% (1/154) 4 Testosterone 14% (21/154) 5 FSH 2% (3/154) M 3 Question Complexity E Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 2 Review Tested Concept Review Full Topic
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