Updated: 5/7/2021

Testosterone

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Mechanism
  • Androgen receptor agonist
Indications
  • Hypogonadism
    • promotes development of male secondary sex characteristics
  • Anabolism
    • promote recovery after severe burn or injury
  • ER-positive breast cancer
    • ↑ testosterone has a negative feedback on LH/FSH leading to ↓ estrogen release
    • testosterone not administered directly
      • exemestane given which is an aromatase inhibitor
Toxicity
  • Masculinization in females
  • Testicular atrophy in males with  
    • decreased gonadotropin-releasing hormone
    • decreased luteinizing hormone
    • decreased follicle-stimulating hormone
    • decreased sperm count
    • increased estrogen
  • Premature closure of epiphyseal plates in adolescents
  • Worsening of lipid profile
    • ↑ LDL, ↓ HDL
    • reason men typically have worse lipids than women
  • Hepatic adenoma 
    • benign mass that can rupture 
    • cause of sudden hypotension in a weightlifter (presumably abusing steroids)

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