Mechanism Androgen receptor agonist Indications Hypogonadism promotes development of male secondary sex characteristics Anabolism promote recovery after severe burn or injury ER-positive breast cancer ↑ testosterone has a negative feedback on LH/FSH leading to ↓ estrogen release testosterone not administered directly exemestane given which is an aromatase inhibitor Toxicity Masculinization in females Testicular atrophy in males with decreased gonadotropin-releasing hormone decreased luteinizing hormone decreased follicle-stimulating hormone decreased sperm count increased estrogen Premature closure of epiphyseal plates in adolescents Worsening of lipid profile ↑ LDL, ↓ HDL reason men typically have worse lipids than women Hepatic adenoma benign mass that can rupture cause of sudden hypotension in a weightlifter (presumably abusing steroids) Erythrocytosis